A day of lectures and collaboration with people in the mathematical and life sciences.
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Program
Ken Dill, Department of Pharmaceutical Chemistry, UC San Francisco
The Protein Folding Problem
We will discuss three related protein folding problems: (1) how folded structures result from the intermolecular forces encoded in the amino acid sequence, (2) how proteins fold so fast, and (3) physics-based methods for protein structure prediction. Folding codes are now being used to design folded structures into non-biological chain molecules. To fold quickly, proteins appear to use a "greedy algorithm", following approximately the routes having the lowest chain-entropy-loss steps. Finally, we find that these physical Zipping & Assembly routes appear to provide a fast way to search conformational space, and may be useful for protein structure prediction.